Managing Infections in Artificial Cornea

Corneal specialists have turned to a keratoprosthesis (Boston keratoprothesis [KPro], Massachusetts Eye and Ear) with increasing frequency over the past decade to address corneal blindness.

Kathryn Colby, MD, PhD, attributes the increase in implantations to changes in the postoperative management—and in the device itself, which has been in use since the 1960s—for the decrease in device extrusion and endophthalmitis. Currently, about 11,000 devices have been implanted.

However, infectious keratitis and endophthalmitis may still develop in up to 18% of cases for several factors, she explained.

“The device is a foreign body without biointegration into the eye that connects the outside world to the interior of the eye,” said Dr. Colby, who is the Louis Block professor and chairman, Department of Ophthalmology and Visual Science, University of Chicago.

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